Discomfort and foreign body sensation in the right lower abdomen may be related to appendicitis, colitis, ureteral stones and so on. 1. Appendicitis: Fecal obstruction in the intestine or bacterial infection spreads to the appendix, inducing inflammation of the appendix, which usually manifests as pain in the lower right abdomen, and may be accompanied by nausea and vomiting, chills, fever, and other symptoms, resulting in discomfort in the lower right abdomen and a foreign body sensation. 2. Colitis: Inflammatory reaction of the colon mucosa may lead to pain in the lower right abdomen, diarrhea and other symptoms, resulting in discomfort in the lower right abdomen and a foreign body sensation. 3. Ureteral stones: Ureteral stones may also cause pain in the lower right abdomen, lumbago, hematuria and other symptoms, resulting in discomfort in the lower right abdomen and foreign body sensation. The discomfort in the lower right abdomen and foreign body sensation, need to go to the hospital in time for examination to clarify the cause of the disease, as soon as possible treatment, to avoid aggravation of the symptoms, affecting the health.