There is no absolute relationship between whether a breast nodule is painful or not and whether it is cancerous or not. Whether a nodule is malignant or not depends on pathological examination, and a biopsy should be taken to make a clear diagnosis. Painful breast nodule does not mean malignancy, on the contrary, most malignant masses do not show localized pain, and most malignant nodules show painless nodules. In the process of diagnosing breast nodules, the nature of the swelling can be initially judged according to the imaging performance, such as whether the appearance is smooth, whether the blood flow is rich, etc. To clarify the nature of the nodule, a coarse needle aspiration biopsy should be performed. It is recommended that breast nodule patients go to regular hospitals to complete the relevant examinations in a timely manner, to clarify the nature of the nodule, and then follow the doctor’s instructions to receive treatment, so as to avoid delaying the condition.