The diagnostic pathology report issued by the major pathology is not necessarily more serious than the biopsy, but in a few cases, it may be more serious than the biopsy results, the specific reasons are analyzed as follows: 1. Biopsy means that the clinician takes part of the tissues or all of the lesions to be sent for examination of the suspected foci or space-occupying lesions, and then decides on the subsequent treatment according to the diagnostic results of the pathological results when they are issued. If the result of the lesion is benign, the clinician may take conservative treatment, close follow-up or regular review; 2. If the result of the biopsy tissue lesion is malignant, the clinician may do further surgical resection treatment and do major pathology. Due to the total tissue or organ resection or radical surgery, the volume of the specimen sent for examination is relatively large and wide, especially for malignant tumors, lymph node dissection or omental tissue clearance will be done, in which case the pathology department will take a larger number of materials and be more comprehensive, and dozens of slices may be made for each case, and more information about the lesion will be provided under the microscope, so it is possible that the final pathological results will be more serious than the biopsy lesion. Than the biopsy tissue lesions are more serious; 3, pathological diagnosis and clinical specimens sent to the site of the material is closely related to whether the accurate, ingenious, so the specimen is also very critical to send a clear material must be taken. In short, in most cases, the biopsy tissue and the results of the major pathology of the main lesions are consistent, in the nature of the disease will not appear too big a gap.