Blisters can be caused by friction, allergic reactions or infections. 1. Friction: Blisters can be caused by friction between the skin and external forces or between the skin. Patients are advised to pay attention to hygiene and cleanliness, and the condition can be self-healing. 2. Allergic reaction: some people may be allergic to external substances such as pollen, which may cause blisters and itchy skin and other allergic manifestations, patients can be treated with anti-allergy therapy, such as oral loratadine and other antihistamines. 3. Infectious factors: viral infections such as herpes simplex, herpes zoster and other viral infectious diseases can cause blisters on the skin. Patients can take antiviral drugs such as acyclovir for treatment. Blisters can also be caused by other diseases such as pemphigus, herpetic pemphigoid, etc. Patients are advised to go to the hospital to find out the cause of the blisters and have them treated. All of the above medications should be used in accordance with the doctor’s instructions.