Treatment of myasthenia gravis

  Myasthenia gravis (MG) is a common condition that is characterized by drooping eyelids, weakness of the limbs with morning and evening weakness, dysphagia and dysarthria, and is closely related to abnormal thymic hyperplasia. More than 80% of patients with myasthenia gravis are known to present with thymic hyperplasia or thymoma. The current clinical detection rate is gradually increasing, with a predominance of young patients.  Expanded thymectomy for myasthenia gravis has become the more effective treatment for myasthenia gravis to date. Expanded thymectomy can effectively relieve and improve the symptoms of myasthenia gravis MG with an efficacy of 80% to 90%.  Usually, thymectomy is recommended in the following cases: (1) myasthenia gravis is not effectively treated with medication; (2) myasthenia gravis patients cannot tolerate the side effects of long-term medication, especially the side effects of hormones; (3) myasthenia gravis is combined with thymic hyperplasia or thymoma.  In recent years, the minimally invasive thoracic surgery technique of TV thoracoscopy for thymic diseases has been carried out in the field of thoracic surgery at home and abroad. It has brought benefits to many young patients with thymoma and thymic hyperplasia combined with myasthenia gravis, especially young female patients. Along with radical treatment, the minimally invasive treatment methods bring more clinical benefits to young patients.  The advantages of TV thoracoscopy for thymic diseases: less trauma, less bleeding, less pain, shorter operation time, faster recovery, shorter hospital stay, and no additional hospital costs. Only three small incisions of 1-2cm are made in the lateral chest wall without causing too much damage to the sternum and ribs, and the operation is easy and can be completed in 1-2 hours. The postoperative pain is mild, and the patient can usually be discharged from the hospital 3-4 days after surgery. The vast majority of surgeries can relieve the cause of myasthenia gravis, and is the treatment of choice for patients with myasthenia gravis combined with abnormal thymic hyperplasia or thymoma. The Department of Thoracic Surgery of Xuanwu Hospital is one of the earlier units to carry out this technique in China.