Upper stage oligosquamous esophageal cancer can usually be treated by endoscopic treatment, surgery, radiotherapy and chemotherapy according to the stage of cancer development. 1. Early stage: For early stage oligosquamous carcinoma of upper esophagus, surgery and endoscopic treatment can be adopted. Surgery can achieve radical effect, while endoscopic mucosal resection or endoscopic ablation is usually less traumatizing and quicker recovery after surgery, while radiotherapy can be chosen when surgery is difficult and microscopic operation is not easy. 2. Progressive stage: For progressive oligosquamous carcinoma of upper esophagus, the treatment is mainly surgery combined with radiotherapy, which is usually carried out within 2-4 weeks after surgery, and commonly used chemotherapy drugs such as carboplatin and cisplatin, etc., and combined with radiotherapy at the same time. Patients with oligosquamous carcinoma of upper esophagus should choose to seek medical treatment as early as possible, combine with the development of the disease, and follow the doctor’s instruction to standardize the treatment, so as to avoid the aggravation of the disease.