Gastric mild enterosis is the replacement of gastric mucosal epithelial cells by intestinal epithelial cells, and intraepithelial neoplasia is the phenomenon of over proliferation of cells and lack of differentiation, which requires different treatment options according to the grading. The degree of intraepithelial neoplasia can be categorized into 3 grades, grade 1 is equivalent to mild atypical hyperplasia, grade 2 is equivalent to moderate atypical hyperplasia, and grade 3 is equivalent to severe atypical hyperplasia, heterogeneous hyperplasia, or carcinoma in situ. grades 1 and 2 usually belong to the low-grade intraepithelial neoplasia, which is mild epithelial abnormality, and surgical resection is recommended for those who have large lesions or those who are accompanied by digestive system and other discomfort symptoms. Grade 3 is a high-grade intraepithelial neoplasia, which is a precancerous lesion, and may progress to malignant tumor if not treated actively, and needs to be surgically removed as soon as possible, and regular gastroscopy is needed after surgery. Patients with mild gastric enterocolitis with intraepithelial neoplasia should pay attention to light diet, quit smoking and drinking, reduce the stimulation to the stomach, maintain a regular work and rest pattern, and avoid staying up all night and mental stress. It is recommended that patients with mild gastrointestinal chemosis with intraepithelial neoplasia go to regular hospitals in time to complete the relevant examinations and standardize the treatment under the guidance of the doctor, so as to avoid delaying the condition or leading to adverse reactions.