Possible causes of total bilirubin 50μmol/L include hepatitis, cirrhosis, gallbladder stones, parasitic infection, etc. Liver-protecting drugs such as diammonium glycyrrhizinate tablets and surgery are needed. 1. Hepatitis and cirrhosis: If the cause of severe elevation of total bilirubin is hepatitis and cirrhosis, liver-protecting treatment is usually needed, such as the use of drugs such as diammonium glycyrrhizinate tablets to protect liver cells and reduce total bilirubin. 2. Gallbladder stones: For the elevated total bilirubin caused by larger gallbladder stones, medication may not be able to reduce the total bilirubin, and laparoscopic cholecystectomy or open cholecystectomy is needed to fundamentally remove the cause of elevated total bilirubin. 3. Parasitic infection: Parasites that invade the liver include Schistosoma oryzae, Ascaris lumbricoides, and Schistosoma, etc. Parasites can lead to blockage of the liver ducts, which can trigger the elevation of total bilirubin. Parasitic infections can be treated with anthelmintic drugs such as albendazole or mebendazole. In severe cases, surgical treatment may also be required. The presence of total bilirubin 50μmol/L suggests timely consultation in a regular hospital and active treatment.