The stomach feels uncomfortable after taking amoxicillin, which is mainly caused by the stimulation of gastric mucosa by such anti-inflammatory drugs, and is prone to stomach discomfort, nausea, vomiting, acid reflux, epigastric pain and other discomforts. Amoxicillin, metronidazole, cefixime, levofloxacin and other antibiotics can easily stimulate the gastric mucosa and cause damage, and in serious cases, may also cause edema, congestion, ulcers and even bleeding of the gastric mucosa. If you experience any of these symptoms, you need to follow your doctor’s advice and get a prescription from a regular physician to decide on the dosage form, dosage and how to take it. The medication can be taken about half an hour after a meal, when there is food in the stomach as a buffer, which can reduce the side effects of the drug. If acid reflux, nausea, heartburn and other reactions are still obvious, you can take omeprazole, bismuth potassium citrate and other drugs before taking amoxicillin orally to inhibit gastric acid secretion, protect the gastric mucosa and reduce irritation to the stomach. If the above measures still do not improve the stomach discomfort, consult your physician if you can change to other kinds of anti-inflammatory drugs. Patients should be careful to avoid self-medication, which may cause discomfort due to improper dosage and dosage form. When taking medication, patients should pay attention to a light and mild diet, not to eat spicy, cold and other stimulating foods such as fried chicken, barbecue, ice-cream, cold drinks, strong tea, coffee, etc. They can eat more liquid foods such as pumpkin porridge, millet porridge, corn paste, oatmeal, lotus seed soup, etc. They can also eat more fresh vegetables such as rape, cabbage, baby vegetables, cauliflower, eggplant, etc. to reduce the burden on the stomach and intestines. Pay attention to the warmth of the abdomen, avoid cold, regular work and rest, do not stay up late, do not overwork.