The efficacy of decitabine is mainly to inhibit tumor proliferation through demethylation, increase tumor cell sensitivity, activation of molecules, etc.; the side effects are myelosuppression, gastrointestinal reactions, etc..
Decitabine is a natural adenosine analog of 2′-deoxycytidylic acid, which inhibits DNA methyltransferase and reduces DNA methylation, thus inhibiting tumor cell proliferation as well as preventing the occurrence of drug resistance, and is the strongest known specific inhibitor of DNA methylation, belonging to the S-phase cell-cycle-specific drugs for the treatment of myelodysplastic syndromes (abbreviated as MDS).
After entering the human body, decitabine can also effectively enhance the sensitivity of tumor cells to the killing of T-lymphocytes and destroy cancer cells. It can also activate molecules through induced action to enhance the expression of important leukemia antigens, so that the tumor immune function increases and promotes recovery.
Decitabine Decitabine kills cancer cells while damaging normal cells, causing bone marrow suppression, leading to a decrease in white blood cells and platelets. It can also gastrointestinal reaction, stimulate the gastrointestinal mucosa causing vomiting, regurgitation, constipation and so on. In addition pregnancy, allergic people need to be used with caution.
Drugs need to be used under the guidance of a doctor, do not blindly use drugs.