There is no necessary connection between elevated liver function index and alpha-fetoprotein, when liver cancer causes serious liver function damage, liver function index and alpha-fetoprotein may appear at the same time. Elevated liver function indexes can be seen in liver damage caused by various reasons, such as viral hepatitis, cirrhosis, autoimmune hepatitis, drug-induced liver injury and so on. Commonly used liver function indicators include serum bilirubin, serum aminotransferase, alkaline phosphatase, and gamma-glutamyl transferase. However, liver function evaluation often needs to refer to a variety of indicators to make a comprehensive judgment. Alpha-fetoprotein is a tumor marker with a positive rate as high as about 70% in patients with hepatocellular carcinoma, thus it can be used as one of the bases for diagnosing hepatocellular carcinoma. In the early stage of liver cancer, when the patient is in the stage of functional compensation, liver function indexes may not be abnormal, but when liver cancer seriously affects liver function, liver function indexes and alpha-fetoprotein may be elevated at the same time. When liver cancer seriously affects liver function, both liver function indexes and alpha-fetoprotein can be elevated at the same time. It is recommended that patients with elevated liver function indexes or alpha-fetoprotein should go to the hospital as soon as possible to find out the causes and then take appropriate treatment.