Chloroquine is an immune modulator. It is now used in the treatment of rheumatic diseases mainly in systemic lupus erythematosus, systemic sclerosis, dermatomyositis, polymyositis, etc. because of its modulating effect. That is, chloroquine may be used in rheumatic immune diseases, except for spondyloarthropathies. However, chloroquine has adverse reactions, mainly blurred vision, so it is recommended to check the fundus of the visual field for any lesions before applying chloroquine, and also to review the fundus after 3 months to 6 months of applying chloroquine to see if there are any adverse lesions, to monitor the lesions of the fundus, and to prevent the side effects of chloroquine. Other side effects are small and generally do not cause liver function damage and kidney damage, so it can be used in rheumatic diseases very widely and commonly and with less reactions. It is important to monitor for allergic reactions, as many patients may develop allergic rash, and some allergies are very difficult to control and cannot be improved for a long time, so we should pay attention to the application of chloroquine.