Sore throat after sleeping may be caused by acute epiglottitis, acute pharyngitis and reflux pharyngitis. 1. Acute epiglottitis: Acute epiglottitis is mainly caused by infection of the epiglottis by pathogens such as Haemophilus influenzae type B, Staphylococcus aureus and Streptococcus pneumoniae. The disease starts rapidly, often occurs suddenly at night, and can cause a sore throat after sleeping. 2. Acute pharyngitis: If viral and bacterial infections of the mucous membrane of the pharynx lead to a sudden onset of acute pharyngitis while sleeping at night, the mucous membrane of the pharynx is stimulated by inflammatory factors, which can cause a sore throat after sleeping. 3. reflux pharyngitis: when due to excessive obesity, gastroesophageal reflux, psychological stress and other reasons suffering from reflux pharyngitis, when sleeping at night, because has been in the supine position, mixed with stomach acid food is more likely to reflux into the esophageal sphincter above the pharynx, the pharyngeal mucous membrane caused by the stimulation, you will feel a sleep a sore throat. If you have a sore throat after sleeping, you should go to the regular hospital to find out the cause of the disease, and choose the suitable method of treatment under the guidance of professional doctors.