The principle of chronic pain treatment is not “treating the symptoms but not the root cause” as most patients and some medical professionals usually understand, but “treating both the symptoms and the root cause”. 1.Block the nerve conduction pathway of nociception. 2.Block the vicious cycle of “pain → muscle tension or small-vessel smooth muscle spasm → local ischemia → tissue hypoxia, metabolite accumulation → increase of pain-causing substances → neuroplasticity reaction → increase of pain”. 3.Reduces sympathetic excitability, dilates blood vessels, improves blood circulation and tissue metabolism. 4.Anti-inflammatory effect, eliminate local non-bacterial and immune neuroinflammation. 5.Improve the patient’s mood, adjust the psychological state, and improve the pain threshold. 6.Relieve the compression of nerves by various lesion tissues such as cervical and lumbar disc protrusion, osteophytes, scar, inflammatory hyperplasia, etc. The treatment means are oral medication, nerve block, anti-inflammatory and analgesic injection treatment at precise lesion site, local nerve chemical destruction treatment, minimally invasive interventional surgery treatment under the guidance of image electrophysiology and other comprehensive treatment.