Osteomyelitis can be caused by various reasons, such as open fracture wound contamination, poor local blood flow to the wound, infection of the internal fixation plate, etc. In addition, the patient’s underlying disease (such as diabetes) can also affect wound healing and eventually lead to bone infection, bone non-healing and even osteomyelitis. The treatment of osteomyelitis generally requires the removal of necrotic tissue (including dead bone), and in some cases, the internal fixation plate (because once infected, the internal fixation becomes a foreign body and can cause repeated local skin breakdown) is removed and replaced by external fixation, and then the corresponding repair method (skin flap or fasciocutaneous flap or myocutaneous flap graft) is adopted according to the results of wound debridement, and sensitive antibiotics are used according to the results of bacterial culture of the wound. anti-infective treatment with sensitive antibiotics according to the bacterial culture of the wound. If there is no bone defect after debridement, it can heal well under the improvement of local conditions after surgery; as for the repair of bone defect after debridement, the corresponding treatment is usually needed about six months after the wound is completely healed: if the bone defect is 4-5 cm, autologous bone grafting can be considered, and bone lengthening surgery is needed for larger defects.