The vaginal opening does not develop acne. Swelling and pain may be caused by folliculitis, vestibular gland cysts, and so on. It can be treated by topical anti-infective drugs, incision and drainage. 1. Folliculitis: The hair at the vulva is exuberant and prone to bacterial infections, causing folliculitis. Topical anti-infective drugs such as mupirocin ointment or fusidic acid cream can be applied locally under doctor’s guidance, and antibiotics such as amoxicillin and cefixime can be taken orally as prescribed by the doctor to shorten the course of the disease if necessary. 2. Vestibular gland cysts: If the vaginal opening is swollen and painful, the possibility of vestibular gland cysts can not be ruled out, and if there is more pus inside, it is necessary to cooperate with the doctor to carry out surgical incision and drainage. After the above situation, the patient should consult a doctor in a timely manner, under the guidance of the doctor to give the corresponding treatment and therapy, do not blindly use drugs.