Lung cancer is one of the most dangerous malignant tumors to human health and life in the world today. The first choice of treatment for lung cancer is surgical treatment, but since 80% of patients are already in the middle and advanced stages of tumor when diagnosed, they lose the opportunity of surgical resection. For unresectable middle and late stage lung cancer, the efficiency of traditional radiotherapy and chemotherapy is only 20%~30%, despite the continuous updating of chemotherapy drugs and radiotherapy techniques. In recent years, the development and popularization of interventional radiology has given patients more chances of recovery and enabled doctors to have more, better and safer treatments, which has increasingly become the preferred method of elective treatment and is highly concerned and welcomed by patients and doctors. The treatment of tumor is also gradually changing from traumatic and destructive treatment mode to a new treatment mode that is precision-guided, minimally invasive and effective. Nowadays, with more and more emphasis on life and survival quality, minimally invasive treatment represented by interventional therapy plays an increasingly important role in the treatment of tumors and leads the development of medical technology in an era. Interventional arterial perfusion therapy uses catheter technology to enter the blood supply arteries of tumors and infuse chemotherapeutic drugs and vascular blocking substances to infuse drugs into tumor tissues, blocking the nutrient supply needed for tumor growth and killing and “starving” tumor cells. Bronchial artery infusion chemotherapy is the earliest and most widely used interventional therapy for the treatment of middle and late stage lung cancer. Experimental results show that the drug concentration in the target organ during arterial infusion is about 4 times higher than that of intravenous drug, and the drug that enters the bloodstream with blood circulation can enter the tumor again, forming a second chemotherapy for the tumor. Therefore, bronchial artery infusion chemotherapy is both local and systemic chemotherapy. Therefore, bronchial artery perfusion chemotherapy is both local chemotherapy and systemic chemotherapy. Bronchial artery perfusion intervention mostly adopts femoral artery cannulation under local anesthesia, and the catheter is selected to the tumor blood supply artery under X-ray surveillance, angiography is performed to confirm the tumor blood supply artery, the catheter and the target artery are fixed, the diluted chemotherapy drug is pumped in slowly with the infusion pump, and the catheter is withdrawn after the perfusion is finished, and the treatment process takes about one hour. Patients need to be bedridden for 6-8 hours before getting out of bed when they return to the ward. According to the pathological type of lung cancer, treatment is given once every 3~4 weeks, and 4~6 cycles are one course of treatment. Here we present a typical case: the patient was a male, 78 years old, admitted with the diagnosis: lung cancer with pleural invasion (advanced lung cancer), pathology: adenocarcinoma. After admission, the patient and his family refused intravenous chemotherapy for fear of side effects of chemotherapy drugs; we did bronchial artery infusion chemotherapy for the patient, using the same chemotherapy regimen as intravenous chemotherapy (gemcitabine and cisplatin), because the patient had more underlying diseases and was an elderly patient, we used the dosage of gemcitabine as 1/8 of the systemic chemotherapy dose and the dosage of cisplatin as After 3 treatments, the lung lesion shrunk very significantly and the patient had almost no side effects of chemotherapy. The following figure shows the changes of the patient’s chest CT and the images during the arterial perfusion intervention: In summary, bronchial artery perfusion intervention has the characteristics of precise positioning, simplicity, safety, small trauma, few comorbidities, quick results, reproducibility, and easy combination of multiple techniques, which have significantly increased and improved the survival rate and quality of life of patients and are increasingly accepted by patients and doctors.