Glioma late-stage mouth outflow may be caused by increased intracranial pressure and swallowing disorder, which needs to be treated with medication and surgery according to the specific condition. In the advanced stage of glioma, there will be manifestations of increased intracranial pressure such as projectile vomiting and severe headache, and there may also be swallowing disorder, which makes it impossible to swallow food or secretions in the mouth, so the patient will have the symptom of things flowing out of the mouth. At this time, it is necessary to use dehydration drugs such as mannitol and glycerol fructose under the guidance of the doctor. For patients who develop hydrocephalus can also reduce intracranial pressure by cerebrospinal fluid drainage. For those with swallowing disorders use nasal feeding tubes or intravenous nutrition. In addition, when glioma is in advanced stage, craniectomy is needed to treat it, and patients need to use chemotherapy drugs such as temozolomide and nimustine as well as radiation therapy under the guidance of doctors after the operation. It is recommended that the patient’s head should be tilted to one side when the patient’s mouth is running, which can prevent the patient from choking. It is recommended that patients with advanced gliomas that are coming out of their mouths should seek medical attention in time, and the doctor will choose the appropriate treatment according to the patient’s condition.