Hepatitis B patients are infected with tuberculosis at the same time, in the process of anti-tuberculosis need to be antiviral treatment at the same time, and regular testing of liver function, according to the changes in liver function to assist liver protection drugs. Hepatitis B patients with tuberculosis need anti-tuberculosis treatment, anti-tuberculosis cycle is long, and anti-tuberculosis drugs have certain damage to the liver. Treatment with anti-tuberculosis drugs may lead to activation of hepatitis B virus, which may lead to liver failure or even death in severe cases, so hepatitis B antiviral drugs, such as entecavir and tenofovir, should be started 1 week before anti-tuberculosis treatment. During the period of anti-tuberculosis treatment, regular outpatient monitoring of changes in liver function is required, especially during the first month of treatment, e.g., total bilirubin, alanine aminotransferase, and aliquot aminotransferase in liver function. When abnormalities are detected, medications such as glycopyrrolate diamine and glutathione should be administered under the supervision of a specialist, and the dose of anti-tuberculosis drugs should be adjusted or discontinued if necessary. The medication should be taken under the guidance of a physician, and should not be taken blindly.