Children with blisters on the back of the hands (blisters) is an abnormal symptom, this situation should be timely medical attention, vigilance is the manifestation of certain diseases, such as hand, foot and mouth disease, chickenpox, sweating herpes and other diseases. 1. Hand, foot and mouth disease: a common infectious disease in children caused by enterovirus infection. Typical clinical manifestations of hands, feet, mouth, buttocks and other parts of the erythema, blisters and ulcers, most of the children have a good prognosis, a small number of rapid progression of the disease, central nervous system damage and cardiorespiratory failure, the condition of the critically ill may lead to death. 2. Chickenpox: acute infectious skin disease caused by varicella-zoster virus infection, mostly seen in children. Typical rash is in the erythema on the basis of blisters with itching, the whole body scattered episodes, blisters were rice to soybean size, blister liquid clear, blister wall is thin, easy to break. 3. Sweat herpes: also known as sweating bad eczema, is a kind of blistering dermatosis occurring in the palms of the hands or soles of the feet, mainly manifested as small blisters in the depth of the skin, the distribution of the denser, may be accompanied by itching, burning sensation. This symptom alone is not enough to diagnose the disease, do not rule out that it is caused by other factors. Parents are advised to bring their children to the doctor in time, ask the doctor to clarify the cause of the disease, give targeted treatment, and avoid children scratching the affected area during the period.