Temozolomide is not recommended to be taken after meals, it is recommended to be taken on an empty stomach, at least 1 hour before a meal. In order to better utilize the medication, patients can take temozolomide before meals and can take antiemetic medication before or after taking the medication. If the patient vomits after taking the drug, the drug cannot be taken again on the same day of taking the drug. Temozolomide is an antitumor drug commonly used in the treatment of glioblastoma multiforme or mesenchymal astrocytoma that recurs and progresses after conventional treatment. Temozolomide is contraindicated in patients who are allergic to the drug, have severe myelosuppression, or are pregnant, and should be used with caution in patients over 70 years of age and in patients with severe hepatic or renal insufficiency. Adverse reactions such as vomiting, nausea, headache, constipation, dizziness and shortness of breath may occur with the use of this drug. This drug may also cause have bone marrow suppression, has some hepatotoxicity, during the use of the drug patients should be regularly checked liver function and blood. Temozolomide should be used under the guidance of a doctor, do not self-medicate.