Hereditary breast cancer is mainly associated with genes such as BRCA1/2, P53 and PTEN, where BRCA1/2 is mainly associated with hereditary breast cancer and ovarian cancer syndrome, P53 is mainly associated with Li-Fraumeni syndrome and PTEN is mainly associated with Cowden syndrome. Li-Fraumeni syndrome-associated tumors are mainly breast cancer, bone and soft tissue sarcoma, leukemia, brain tumors, adrenocortical carcinoma, choroid plexus tumors, colon cancer, and pediatric tumors. The main Cowden syndrome-related tumors are early-onset breast cancer, thyroid cancer, misshapen lesions (skin, breast, and intestine, including oral mucosal papillomas and warts of the extremities and toes), macrocephaly, endometrial cancer, and some benign lesions of the breast and uterus. Others are dyskinetic capillary dilation (manifested by capillary dilation of the eyelids, cerebellar ataxia, immunodeficiency, leukemia, and susceptibility to lymphoma), Peutz-Jeghers syndrome (manifested by misshapen polyps of the gastrointestinal tract and melanosis of the skin mucosa), Muir-Torre syndrome (multiple sebaceous gland and skin tumors with concomitant small bowel, large bowel, larynx Muir-Torre syndrome (multiple sebaceous gland and skin tumors with tumors of the small intestine, large intestine, larynx, stomach, endometrium, kidney, bladder, ovary and breast) is associated with a high risk of breast cancer. If a family member has one of the diseases described in the above syndrome, it is important to be aware of the risk of hereditary development of breast cancer and to analyze family information for genetic analysis.