High direct bilirubin and total bilirubin may be caused by bile duct stones, acute suppurative cholangitis, cholangiocarcinoma, and pancreatic cancer and other diseases.
1. Choledochal stones: patients with choledochal stones will cause obstruction of bile discharge, which will easily cause bile to flow back into the blood, and patients will develop obstructive jaundice. At this time, patients will have increased direct bilirubin and total bilirubin in liver function tests.
2. Acute septic cholangitis: acute septic cholangitis will lead to a large amount of bile stagnation in the bile ducts, and the patient will experience bile duct dilatation, and the bile will enter the blood sinusoids or tissue interstitial space at this time. When the patient undergoes liver function test, the test result will be elevated direct total bilirubin and elevated direct bilirubin.
3. Cholangiocarcinoma: bile excretion of patients with cholangiocarcinoma is not smooth, which will easily cause obstructive jaundice. When patients do liver function test, serum total bilirubin, direct bilirubin and alkaline phosphatase will be increased.
4. Other: patients with increased direct bilirubin and total bilirubin in liver function tests are also considered to be caused by pancreatic cancer, biliary ascariasis, hepatocellular carcinoma and other diseases.
It is recommended that patients with high direct bilirubin and total bilirubin should consult a doctor in time, and the doctor will choose appropriate measures to treat them after clarifying the cause of the disease.