In clinical practice, there are many patients with neck, shoulder, back and leg pain who, for various reasons, are unwilling to undergo surgery, while the usual conservative treatments, such as acupuncture, massage and Chinese herbal medicine, have all been used, so is there really no other way? In fact, small needle knife is a very effective way to treat neck, shoulder, back and leg pain. We follow the principle of conservative treatment → minimally invasive treatment → surgery for neck, shoulder, back and leg pain. If the effect is not good, we should choose minimally invasive treatment, such as small needle knife, ozone, radiofrequency ablation, discoscopy, etc. If the effect is still not good, it means the lesion is too serious, so we must open surgery. In the minimally invasive treatment, we choose small needle knife as the first choice, under local anesthesia by loosening the knife blade of about 0.8 mm wide to loosen the abnormal pain reflecting points, the soft tissues around these abnormal pain points are often where the pain-causing substances accumulate, and are in an abnormally high pressure state, needle knife loosening can reduce the local tissue pressure, so that the pain-causing substances can be released, thus relieving pain. We have found that the treatment of cervical spondylosis, frozen shoulder, lumbar disc herniation, lumbar spinal stenosis, lumbar spondylolisthesis, etc. is really unique in the treatment of cervical and lumbar pain with small needle knife.