Chronic sinusitis has the potential to become cancerous, and the timing of the cancerous transformation is uncertain. The transformation of this disease to cancer is mainly related to chronic inflammatory stimulation, exposure to carcinogenic substances and malignant transformation of benign tumors. Nasal cancer is mainly squamous epithelial carcinoma, the incidence of which is mostly found in maxillary sinus. It is suggested that patients should follow the doctor’s instructions to avoid delaying the condition. 1. Long-term chronic inflammation stimulation: chronic sinusitis stimulates the nasal mucosa for a long time, which will make the columnar epithelium in the nasal mucosa turn into squamous epithelium, laying the foundation for the occurrence of changes, so timely and standardized treatment of chronic sinusitis has positive significance for the prevention of the occurrence of cancer. 2. Frequent exposure to carcinogenic substances: long-term inhalation of heavy metal elements such as nickel, copper, etc. may increase the risk of sinusitis cancer. 3. Malignant transformation of benign tumors: if the patient suffers from involutional papilloma, under the premise of multiple surgeries, combined with the stimulation of sinusitis, it may cause cancerous transformation.