There are no new drugs that can turn hepatitis B negative. A complete cure for hepatitis B includes the removal of all hepatitis B viruses from the blood and liver cells to achieve negative hepatitis B surface antigen, negative hepatitis B DNA, completely normal liver function, normal imaging tests, and no symptoms. Nowadays, the recommended first-line antiviral drugs are mainly entecavir and tenofovir, which only inhibit the replication of the hepatitis B virus, but cannot completely remove the hepatitis B virus from the blood. For hepatitis B carriers, if the liver function is completely normal and there is no episode of hepatitis, they are healthy carriers and generally do not need to take any oral medication for treatment, and their life expectancy is the same as that of healthy people. If there is any discomfort, it is recommended to go to the hospital in time to get a clear diagnosis and treatment, so as not to delay the condition.