There is a hard bag on the thumb that hurts when pressed for more than ten years may be caused by tendon sheath cysts, chondroma, gout and other reasons. 1. Tendon sheath cysts: tendon sheath cysts are mostly related to the long-term stimulation of joint injury, a few patients have a history of repeated minor trauma before the onset of the cysts are mostly hemispherical and elevated in the joints under the skin, usually no obvious symptoms, when the cysts are too large, it will cause local compression, and the symptom of pressing pain. 2. Chondrosarcoma: chondrosarcoma is usually caused by radiation pollution, infection, heredity, etc. Chondrosarcoma proliferates slowly, and with the enlargement of the lump, it will have the symptom of pressure pain or hidden pain, which mostly occurs in the bones of the hand. 3. Gout: Gout may be caused by excessive intake of alcohol, drug-induced, excessive intake of purine-rich foods, etc. Gout stone will appear in the joints of patients at the onset of the disease, which is mainly manifested in the hard lumps in the joints of the fingers, and some of the patients will also be accompanied by symptoms such as accelerated heart rate, fever, and chills, etc. If you have any symptoms, you should go to the hospital promptly. If you have symptoms, you should go to the hospital in time, after diagnosis, under the guidance of the doctor for treatment.