Megakaryocytes do not produce platelets need to be treated according to different causes, and common causes include aplastic anemia, drug-induced myelosuppression, immune thrombocytopenic purpura, leukemia and so on. 1. Aplastic anemia: the main feature of aplastic anemia is bone marrow hematopoietic dysfunction, leading to a decrease in megakaryocytes, and then a decrease in platelet production. Treatment is supportive therapy such as avoiding infection and bleeding, correcting anemia, and immunosuppressive therapy using anti-lymphocyte/thymocyte globulin and cyclosporine. Androgens such as testosterone undecanoate can also be used to promote hematopoiesis, and hematopoietic stem cell transplantation can be performed if there is a suitable donor. 2. Drug-induced myelosuppression: alkylating agents, antimetabolites and cytotoxic drugs used in the treatment of tumors, such as cytarabine, etc., will cause myelosuppression, resulting in the reduction of megakaryocytes and platelets, and the drugs should be discontinued or the program of drug use should be changed at this time. 3. Immune thrombocytopenic purpura: immune-mediated reduction of platelet-producing megakaryocytes, excessive platelet destruction, critical condition, the need for platelet transfusion, intravenous infusion of gammaglobulin and methylprednisolone. Megakaryocytes do not produce platelets for many reasons, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the physician to give targeted treatment or treatment.