Probably because I have done some work and research on thymoma and myasthenia gravis in recent years, there are more and more patients with thymoma combined with myasthenia gravis in my outpatient clinic. Is thymoma combined with myasthenia gravis scary? Is it an incurable disease? Thymoma and myasthenia gravis are two different diseases, but they are inextricably linked to each other. In a subset of patients, they can co-exist. This is indeed a rather troublesome clinical situation, where doctors need to balance oncological principles (thymoma) and immunological principles (myasthenia gravis), and the clinical situation can be complicated, with great differences between individuals, and one treatment model cannot be used to treat all patients; as early as several years ago, I made thymoma and myasthenia gravis one of my main clinical research directions, and after reviewing Zhongshan Hospital Based on the rich experience of previous treatment, I was the first in China to carry out bilateral thoracoscopy + small neck incision for myasthenia gravis (combined or not combined with thymoma). In my not too long clinical experience, I have successfully managed many patients in this area. Dozens of such patients have been treated very well, and so far, all of them have had no tumor recurrence, all of them have improved to varying degrees, and a significant number of them have been completely off medications. So this disease is a bit troublesome, but not incurable. Can this disease be seen well? Does it require surgery? As mentioned earlier, a significant number of patients are seen with very good results, but the individualization is very different and I tailor the treatment to each patient. Thymoma itself has a good prognosis, and cases with combined myasthenia gravis tend to be detected early, and the tumor itself is not too advanced, so the treatment outcome is excellent. This disease has strong indications for surgery and as long as there are no absolute contraindications to surgery, it should be treated early by surgery to obtain the best treatment results. If surgery is needed, when is the best time to operate? Myasthenia gravis is complex and has a variety of ways of starting the disease. We should be particularly aware of a situation where a small number of patients who are not severe when the disease starts will progress rapidly and become very severe in a short period of time. Such patients would be potentially at risk if operated on. Therefore, when a new mild case develops in a short period of time, our medical team usually does not take it lightly and can consider short-term internal medicine examination and management followed by a period of time, and if the condition is stable, surgery can be considered. Of course, if the patient’s condition is more severe, such as respiratory muscle involvement or severe medullary muscle involvement, we will appropriately extend the preoperative preparation time to allow the hormone shock therapy to take effect before doing surgery will be safer. This is our initial experience. What are the key points of perioperative management? Thymic disease is very complex and often involves the coordinated management of multiple disciplines. The core issue is to avoid postoperative myasthenia gravis crisis. Objectively speaking, this is where general hospitals have the advantage.