Dry syndrome is an autoimmune disease, mainly involving exocrine glands, and some patients can involve multiple organs and systems such as respiratory system, kidney, blood, etc. Treatment can be divided into Chinese and Western medical treatment. Western medicine treatment modalities: 1. Symptomatic treatment: mainly to improve the symptoms of dry mouth and dry eyes. In daily life, we should stop smoking, drinking alcohol and avoid taking drugs that cause dry mouth, keep the mouth clean, which can reduce the occurrence of dental caries and oral secondary infections, which can alleviate the symptoms of dry mouth to some extent; reduce excessive eye use, keep the environment moist, and use artificial substitutes such as artificial tear glands and saliva can reduce the symptoms of local dryness. M3 receptor agonist (pilocarpine) has become a new generation of improving dry mouth and eyes drugs. Tear spot tethering can also reduce dry eye symptoms. The total glucoside of peony and hydroxychloroquine are also widely used in the basic treatment of dryness syndrome at present. 2.Systemic treatment: For patients with important organ or system involvement, such as renal tubular acidosis, interstitial lung fibrosis, neurological involvement, thrombocytopenia, etc., glucocorticoids, immunosuppressants and other active treatments can be given. Specific drug selection and dosage vary greatly according to different situations. 3. Other symptomatic and complication management: correction of acute hypokalemia is based on intravenous potassium supplementation, and after stabilization, oral potassium salt tablets are given instead, and some patients need to take them for life to prevent the reoccurrence of hypokalemia. Combined with primary biliary cholangitis give ursodeoxycholic acid treatment. Non-steroidal anti-inflammatory is effective for muscle and joint pain. The presence of malignant lymphoma is appropriate to actively carry out combined chemotherapy for lymphoma. 4. Biological agents: anti-CD20 monoclonal antibody can inhibit B-cell production and is effective in patients with refractory or active B-cell function. From the perspective of Chinese medicine, it belongs to the range of deficiency labor, yin deficiency or blood deficiency and wind dryness, resulting in local or systemic symptoms with dryness as the main feature. Treatment is based on benefiting Qi, nourishing Yin and moistening dryness. Mainly by nourishing the liver and kidney and regulating the transportation and transformation function of the spleen, this kind of transportation and transformation function of the turbidity can make the dry mouth, dry eyes and swollen parotid glands of dry syndrome patients be relieved. Patients with dry syndrome need to replenish essential vitamins in their bodies, drink more water to avoid dry lips, have good living habits, work and rest on time, refuse to stay up late, eat regularly and follow medical advice.