Azithromycin can be combined with doxycycline, but it needs to be used under a doctor’s supervision. Azithromycin is a macrolide antibiotic drug, can play a good antibacterial effect on gram-positive bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes and other gram-negative bacteria such as Haemophilus influenzae, Neisseria gonorrhea and other pathogens, as well as chlamydia and other pathogens. Doxycycline is a tetracycline antibiotic drug with broad-spectrum antibacterial effect, Mycoplasma spp, Chlamydia spp, Rickettsia spp, Mycobacterium avium subspecies, Helicobacter spp, and other pathogens are sensitive to this drug. Azithromycin and doxycycline are not contraindicated between these two drugs, so these two drugs can be used in combination, but must strictly follow the doctor’s instructions. Adverse reactions: azithromycin and doxycycline use, caused by the common adverse drug reactions is the gastrointestinal reaction, mainly manifested as diarrhea, abdominal pain, nausea, vomiting and so on. Contraindications: Azithromycin needs to be contraindicated in people who are allergic to azithromycin or who have a history of hepatic insufficiency with previous use of azithromycin. A history of tetracycline allergy requires doxycycline, and doxycycline is also contraindicated in children under 8 years of age. Note: Whether using azithromycin or doxycycline, once a secondary infection occurs, the medication should be discontinued immediately and appropriate measures should be taken to deal with it. In addition, individuals should pay attention to the regular examination of liver function and blood routine if they use the drug for a long time. Individuals should do scientific and rational use of azithromycin and doxycycline, and should never abuse them to avoid some adverse consequences.