Tacrolimus is irritating to the pancreas and can cause acute and chronic pancreatitis attacks, so it should be used under the supervision of a doctor. Tacrolimus is an immunosuppressant, mainly used to prevent rejection after liver and kidney transplantation, during the use of the drug may lead to infection or make the original infection worse, but also may produce thrombocytopenia, diabetic ketoacidosis, electrolyte disorders, hypoproteinemia, mental anomalies, tinnitus, blurred vision, and other reactions, also acute and chronic pancreatitis can occur. Those who are allergic to tacrolimus as well as other macrolides should be prohibited from using it. During the use of the drug should pay attention to rest, strengthen exercise, improve the immunity of the body. Please strictly follow the doctor’s instructions for drug treatment, do not use drugs on your own.