Antihistamines are preferred for the treatment of urticaria, and antihistamines can be divided into the first and second generation. The representative drugs of the first generation are ketotifen, cyproheptadine, paracetamol, etc. The second generation antihistamines are more diverse, such as cetirizine, desloratadine, fexofenadine, epalmatine, imipramine, etc. Glucocorticoids, such as prednisone, dexamethasone and methylprednisolone, can be used for patients with acute generalized urticaria or those with a tendency to anaphylaxis, but care should be taken to monitor adverse reactions and side effects when using them. Vitamin C and calcium gluconate can reduce capillary permeability, reduce edema and itching symptoms, and also treat acute urticaria. Other anti-allergic drugs, such as compound glycyrrhizin tablets, the Chinese medicine Yu Ping Feng granules, anti-itch granules, and urticaria pills can also treat acute and chronic urticaria.