1. Heredity The occurrence of diabetic nephropathy has a certain family aggregation. 2. Difficult to control the high blood sugar This is the most fundamental reason. 3, high blood pressure is the accomplice of uremia, systolic blood pressure for a long time is greater than 140mmHg , kidney function will decline at a rate of 6% per year. 4, high dietary protein intake may increase the burden on the kidneys, resulting in an increase in urinary albumin excretion. 5, other factors smokers, hyperlipidemia.