Spider nevus of liver cancer is often more common on the front chest wall and upper limbs, and is also seen in other parts of the body. Spider nevus caused by liver cancer is a clinical manifestation due to abnormal liver function, which causes abnormal inactivation of estrogen, resulting in abnormal estrogen level in the blood. Spider nevus is most common on the chest and upper limbs, manifesting as red burr-like nevus, often accompanied by symptoms such as grayish color and swelling. Liver cancer is often combined with cirrhosis, and liver cancer will further aggravate the degree of liver function abnormality, so liver cancer often progresses faster. Patients with spider nevus need to comprehensively evaluate their general condition and timely carry out symptomatic treatment such as liver preservation and albumin supplementation to prolong their survival period as much as possible.