Metformin extended-release tablets and simvastatin can usually be taken at the same time, but the specific dosage and frequency of use need to consult a professional doctor. 1. Metformin extended-release tablets: it is an oral hypoglycemic drug, belonging to the class of biguanide, which lowers blood glucose by inhibiting the input of hepatic glucose and increasing the utilization of glucose. It is the first-line drug for type 2 diabetes mellitus and is suitable for patients with poor glycemic control under simple diet and exercise therapy. 2. Simvastatin: It is a lipid-lowering drug used for hypercholesterolemia and also for secondary prevention of coronary heart disease. When dietary therapy and other non-pharmacological treatments are ineffective, simvastatin can be applied to lower total cholesterol and LDL cholesterol in patients with primary hypercholesterolemia. Metformin extended-release tablets and simvastatin can be taken at the same time, but can not be blindly used on their own, need to be taken under the guidance of a doctor, follow the doctor’s instructions to develop the dose and the number of times to take.