There is no such thing as the best medicine for leg pain, it should be treated according to the cause, the common causes of leg pain are trauma, osteoporosis, lumbar spine disease, vascular disease, etc., you can follow the doctor’s instructions to give oral analgesia, nerve nutrition, calcium, antiplatelet and other drugs for treatment. 1. Trauma: trauma can lead to leg bone and soft tissue injury, local swelling, bruising, pain and other manifestations, can be prescribed oral analgesic drugs such as celecoxib, ibuprofen and other anti-inflammatory treatment. 2. Osteoporosis: mostly seen in long-term bed-ridden or elderly patients, osteoporosis is caused by calcium loss or insufficient intake of calcium, low calcium can cause increased neural excitability, resulting in limb muscle spasm, soreness and other discomforts, can be prescribed oral calcium gluconate, calcium carbonate and other medications, as well as supplemental vitamin D, alendronate sodium and other drugs for treatment. 3. Lumbar spine disease: compression of nerves by lumbar disc herniation can lead to pain and discomfort in the leg and other innervated areas, which can be treated by taking anti-inflammatory and analgesic medicines such as ibuprofen and diclofenac sodium as prescribed by the doctor as well as nutritive nerve drugs such as methylcobalamin. 4. Vascular disease: lower extremity vascular embolism, arterial occlusion, vasculitis and other diseases can cause local ischemia, which can lead to soreness in the legs, according to the condition of the oral aspirin, clopidogrel and other antiplatelet drugs as prescribed by the doctor, but also with the use of lipid-lowering drugs such as atorvastatin. When the calf pain should be timely medical consultation and treatment, clear condition under the guidance of specialists in the application of targeted drugs.