Anal pruritus is a skin disease in which the skin around the anus does not have any primary skin damage but only pruritus symptoms. More men than women, preferably in those who are usually inactive. Clinical manifestations 1, pruritus Initially limited to perianal skin itching, paroxysmal, often at night, quiet, emotional changes, diet spicy food, moisture and heat intensified, the heavy itching unbearable. 2, pain The itching is sometimes light and sometimes heavy, sometimes stinging or burning pain. Due to scratching the skin ulceration, oozing, nodules, long-term. Perianal eczema is a common non-infectious skin disease, lesions are mostly limited to the skin around the anus, but also occasionally spread to the buttocks, perineum and clitoris, local rash, erythema, erosion, oozing, crusting, flaking. With a long course, the skin around the anus is often thickened, grayish or dark red and rough, resulting in chapping, exudation, itching and recurrent attacks as the main features, which can develop at any age. Clinical manifestations 1, acute eczema Any part of acute eczema generally follow the process of flushing – papules (maculopapular) – blisters (exudate) – vesicles – crusts (scales) – pigmentation new, accompanied by pruritus. The clinical manifestations are marked plasma exudation, or in strict cases, dripping exudation, intense itching that is difficult to tolerate, scratching that results in scratches, hemorrhagic crusts, and combined bacterial infections that result in pustules, purulent exudates, and purulent crusts, presenting the characteristic appearance of eczema, i.e., multiple types of rashes exist simultaneously. The anal skin is a sensitive area, acute eczema itching is particularly intense, fecal contamination is more likely to cause bacterial infection, the symptoms are heavier, can be extended and perineum, scrotum, buttocks skin, affecting the patient’s life and work, so the course of the disease is extremely unstable, the treatment process is prolonged, and turned into a chronic process. 2, chronic eczema perianal chronic eczema is more common than acute eczema, local manifestations of skin thickening, tinea changes, creases chaps obvious, tendency to exude, itching intense, chronic, easy to recur. 3, subacute eczema by acute eczema inflammation reduction, not timely treatment, delayed for a long time. Characterized by lesions with small papules, scales and crusts, only a few papules and blistering vesicles. The most common type of dermatitis is anal contact dermatitis, which is caused by the transmission of blood and can be self-inflicted. Anal contact dermatitis is a cellular immune response delivered through lymphocytes. Clinical manifestations Skin damage is acute, with marked erythema, edema, papules, and in severe cases, blisters with clear margins, self-induced burning itching or pain, and even development of erosion, infection, and pus. Perianal purulent sweat gland inflammation Purulent sweat gland inflammation is a wide range of inflammatory skin disease formed in the skin and subcutaneous tissues after sweat gland infection, perianal subcutaneous tissue is one of the favorite sites, multiple sweat gland infection, pus flow, repeated episodes of formation of connected subcutaneous fistula. Clinical manifestations 1. Single or multiple small red, swollen nodules, boils and pustules of the same size as the hair follicles may appear in the perianal skin at the initial stage, mostly breaking down naturally and flowing out of a viscous, foul-smelling purulent secretion. 2. Inflammation is sometimes mild and recurrent, gradually forming subcutaneous ulcers, sinus tracts and fistulas. Sinus tracts can develop from one to more than ten. Many of the sinus tracts are subcutaneously connected and fused together, and the sinus tracts generally surround the anus for several centimeters, and the fistulae can be more than a dozen. The lesions are only located subcutaneously and do not communicate with the rectum or anal fossa, and some of the local skin is scarred. 3. Systemic symptoms: fever, headache, malaise, elevated white blood cells, loss of appetite, painful enlargement or wasting of lymph nodes, anemia, hypoproteinemia, endocrine and fat metabolism disorders, etc. Syphilis Syphilis is a chronic, systemic sexually transmitted disease caused by the pale (syphilis) spirochete. It is mainly transmitted through the sexual route and can be clinically manifested as stage I syphilis, stage II syphilis, stage III syphilis, latent syphilis and congenital syphilis (fetus-borne syphilis). It is a disease listed as category B in the Prevention and Control of Infectious Diseases Law of the People’s Republic of China. Clinical manifestations 1. Acquired dominant syphilis (1) Stage I syphilis. The hallmark clinical feature is hard chancre. The most common sites are penis, glans, coronal sulcus, foreskin, urethra; labia, clitoris and cervix; anus and anal canal. It can also be seen on the lips, tongue and breast. (2) Stage II syphilis. TP spreads with blood circulation and causes multi-location damage and various lesions. It invades the skin, mucous membranes, bones, internal organs, cardiovascular and nervous systems. When syphilis enters stage II, the syphilis serology test is almost 100% positive. Systemic symptoms occur before the appearance of the rash, with fever, headache, bone and joint pain, hepatosplenomegaly, and lymph node enlargement. The incidence is about 25% in males and 50% in females. 3 to 5 days to improve. Then syphilis rash appears and is characterized by recurrent occurrence. (3) Stage III syphilis. 1/3 of untreated overt TP infections develop stage III syphilis. Among them, 15% are benign late syphilis, and 15%-20% are severe late syphilis. 2.Acquired latent syphilis Acquired TP infection does not form dominant syphilis and is asymptomatic, or dominant syphilis after a certain period of activity, the symptoms temporarily subside, syphilis serologic test positive, brain crest fluid examination is normal, known as latent (latent) syphilis. Those within 2 years after infection are called early latent syphilis; those more than 2 years after infection are called late latent syphilis. 3, Pregnancy syphilis Pregnancy syphilis is a dominant or recessive syphilis that occurs during pregnancy. In gestational syphilis, TP can be transmitted to the fetus through the placenta or umbilical vein, forming congenital syphilis in the baby born later. The occurrence of small arteritis in pregnant women leads to placental tissue necrosis, resulting in miscarriage, premature birth and stillbirth, and only a few pregnant women can have healthy babies. 4. Congenital dominant syphilis (1) Early congenital syphilis. The child is thin at birth, and the symptoms appear 3 weeks after birth, with enlarged lymph nodes, no adhesions, painless and hard. Most of them have syphilitic rhinitis. Skin lesions appear about 6 weeks after birth as blistering-herpetic lesions (syphilitic aspergillosis) or maculopapular or papulopapular scaly lesions. Osteochondritis and osteochondritis may occur. There is mostly hepatomegaly and splenomegaly. Thrombocytopenia and anemia. Neurosyphilis may occur. Sclerosing chancre does not occur. (2) Late congenital syphilis. Occurs after 2 years of age. One type is permanent damage to bone, teeth, eyes, nerves and skin due to early lesions, such as saddle nose, Hao Qin Sen teeth, etc., without activity. The other category is the clinical manifestations due to still active damage, such as keratitis, neurological deafness, abnormal neurological performance, brain crest fluid changes, hepatosplenomegaly, nasal or jaw dendrites, joint effusion, periostitis, dactylitis, and skin mucosal damage, etc. 5, congenital latent syphilis born in the mother with syphilis, untreated, no clinical manifestations, but syphilis seropositive, less than 2 years old for early congenital latent syphilis, more than 2 years old for late congenital latent syphilis. It is a good idea to have a good look at the website. The disease develops after an incubation period of about half a month to 8 months, with an average of 3 months. The disease is more common and is mainly transmitted through sexual contact. The incubation period is 1 to 8 months, an average of 3 months, mainly occurs in sexually active people. 1, the typical condyloma genital and perianal as the site of prevalence, men are seen in the foreskin, tie, coronal groove, glans, urethra, penis body, perianal, rectal and scrotum, women are seen in the labia, posterior union, vestibule, clitoris, cervix and perianal. Occasionally, it is seen in areas other than the pubic and perianal areas, such as the axilla, umbilicus, oral cavity, breasts, and between the toes. Vaginitis in women and male circumcision are contributing factors to the development of acromegaly. The damage starts out as tiny reddish papules, which gradually increase in size, individually or in clusters, moist and soft, with an uneven surface, papilla-like, corkscrew-like or cauliflower-like protrusions. Red or dirty gray. The roots are often tipped and prone to erosion and oozing, and bleed easily when touched. The lesions often have purulent secretions between the cracks, resulting in a foul odor, and can cause secondary infection due to scratching. The actual fact is that you can find a lot of people who are not able to get a good deal on a lot of things. The actual fact is that you can find a lot of people who are not able to get a lot of money for the purpose of the actual project. The actual HPV infection is not clinically recognizable to the naked eye, but is found to be locally white after the white acetate test (applied with 5% acetic acid solution or wet compress), histopathology or nucleic acid testing techniques can find evidence of HPV infection. 3.Relationship with tumor A large amount of epidemiological data indicates that HPV infection (mainly high-risk HPV, such as HPV-16 and 18) is closely related to the occurrence of genital cancer, such as cervical cancer and penile cancer. The prognosis is generally good after treatment. However, regardless of the treatment method, recurrence is possible.