Patients with acute suppurative osteomyelitis can be treated by applying antibiotics, braking the affected limb, surgical treatment, and supportive therapy as follows: First, the application of antibiotics: the combined use of antibiotics can kill bacteria and improve inflammation. Clinical need to do bacterial culture and drug sensitivity test, to confirm the causative bacteria, choose the most suitable antibiotics for treatment, can play the best therapeutic effect, but also to avoid adverse reactions. Second, braking of the affected limb: skin traction and plaster rest can be used to brake the affected limb to reduce local pain and avoid the spread of inflammation, as well as to prevent pathological fracture. Third, surgical treatment: including open window drainage, which can remove the primary lesion of infection. Fourth, supportive treatment: Patients suffering from acute septic osteomyelitis consume a lot, so they should receive appropriate blood and fluid transfusions, supplement vitamins, strengthen nutrition and improve immune status.