In July 2007, the Ministry of Health issued a notice that with the development of clinical medicine in China and the increase of patients’ demand for medical services, it was decided to add the subject of “pain medicine” to the “Medical Institution Diagnostic and Treatment Catalogue”. The new “pain department” belongs to the first level of diagnosis and treatment, and its main scope of business is the diagnosis and treatment of chronic pain. With the further understanding and recognition of this new discipline, the unremitting efforts of the medical and nursing staff of the pain department and the standardized treatment and operation, and the concern and support of the leaders from all walks of life, the pain discipline has been developing like a spring. With the development of the pain discipline, the pain department can not stay in the “closed” treatment and give a few analgesics on the impression of small prescriptions to treat pain, pain department pain treatment how more specialist characteristics, is an important issue for us to consider! A pain specialist physicians should be high standards, strict requirements. As a new discipline, the development of pain is itself a result of multidisciplinary coordination and comprehensive development, often crossed with neurology and surgery, orthopedics, rehabilitation, Chinese medicine and anesthesiology in the treatment of pain. Each traditional specialty has its own unique and mature concept of pain management, but it is a great challenge for pain specialists to reflect the specialty characteristics of our pain department, or even to surpass traditional departments in some aspects of pain management, or at least to reflect that we have more pain management measures. This requires us to know the anatomy of all parts of the body (including blood vessels, muscles, nerves and bones), unlike obstetrics and gynecology, which specializes in pelvic lesions such as uterus and adnexa, or neurosurgery, which is based on the central and peripheral nerve lesions of the whole body. Pain specialists need to know the nature of trigeminal neuralgia, the characteristics of pain, what drugs are effective, and what methods can save money and solve the problem at root, as well as what pain is related to muscle strain and pressure on peripheral nerves, what pain is related to misalignment of small joints, what pain is related to nerve compression by herniated discs, and what pain is related to spinal stenosis. Only when we are proficient in the anatomy and pathophysiology of each disease, collecting the nature of pain of this onset, pain characteristics and accompanying symptoms, combined with imaging and laboratory tests, we can confirm the diagnosis of each disease. However, because pain can be only a patient’s complaint and is related to many factors, it is clinically prudent for us to diagnose a disease and do a lot of differentiation. The pain specialist should be able to develop a “golden eye”, a glance to determine the pain, multiple measures to remove the pain. The mechanisms of chronic pain are complex, including central sensitization of the spinal cord, ectopic firing activity of damaged nerves, abnormal nociceptive receptors or ion channels and central nervous system remodeling. There are many ways to classify chronic pain, except for the classification according to the affected site, the more frequently used classifications are: 1. injury-receptive pain, i.e., pain characterized by throbbing, aching or dull pain due to trauma or disease stimulating injury receptors and activating injury transmission pathways in the central nervous system; 2. neurogenic pain, due to pathological changes in the peripheral or central nervous system resulting in neuronal The pain is caused by abnormal excitation, spontaneous discharge and pseudosynaptic transmission, which is characterized by burning pain, radiating pain, pins and needles pain or electric shock pain; 3. Mixed pain, which is characterized by both injury-receptive pain and neurogenic pain, such as cancer pain. Therefore, our pain specialists should make use of their expertise in identifying various types of pain and use different treatment measures such as drugs, pain point injection, nerve block, nerve compression release and various minimally invasive treatment methods to remove pain and protect nerves to a great extent. Third, flexible medication for neuralgia. If we are familiar with the nature of various types of pain, we can use targeted medication to control the pain to improve the quality of life of the patient and gain time for our next minimally invasive treatment. For example, in postherpetic neuralgia, some patients have burning pain, and amitriptyline is effective; some patients have pinprick-like or discharge-like pain, and antiepileptic drugs such as gabapentin and pregabalin are preferred; for trigeminal neuralgia, carbamazepine is effective; for lumbar disc herniation, nerve entrapment causes discharge-like lower limb pain, NSAIDs combined with antiepileptic drugs are effective. In addition, most patients with neuralgia are accompanied by depression, so in addition to patiently guiding patients to relieve their anxiety, it is more important to apply antidepressants and sedative drugs to improve the pain threshold and relieve symptoms, which can help improve the effect of pain treatment. Fourth, a variety of minimally invasive methods are combined to treat pain, which are safe, effective, less invasive and less expensive. ①Treatment of primary trigeminal neuralgia by radiofrequency thermal coagulation of the trigeminal nerve hemianopia through the foramen ovale. ②Cervical and lumbar disc herniation targeted radiofrequency thermocoagulation for cervical and lumbar disc herniation. ③Ozone ablation of cervical and lumbar discs for cervical and lumbar disc herniation. ④cervical and lumbar disc herniation target point collagenase treatment, collagenase external disc lysis for cervical and lumbar disc herniation. ⑤ CT or DSA-guided dorsal root ganglion pulsed radiofrequency treatment for intractable postherpetic neuralgia. ⑥Intervertebral foraminoscopy, more targeted treatment of lumbar disc herniation under direct vision. (7) Implantable spinal cord electrical stimulation for intractable refractory neuralgia (8) Implantable morphine pump, hope for pain-free cancer pain patients