Irritable bowel syndrome is characterized by unexplained abdominal discomfort or pain accompanied by abnormal bowel movements. Typical IBS is characterized by abdominal pain or discomfort that is relieved by defecation (this is the main difference from functional diarrhea), or by a change in the frequency of defecation (increase or decrease), or a change in the stool characteristics (thinning or hardening) during an episode. However, the stool must be free of pus and blood, no incomplete bowel movements, no significant weight loss, and the stool does not interfere with sleep. If the patient does not have red alert signs such as gastrointestinal bleeding, weight loss, fever, anemia, or abdominal masses. Refractory IBS must meet the following criteria: Required: 1. Diagnosis meets Rome III criteria (recurrent episodes of abdominal pain or discomfort with symptoms on at least 3 days per month for the last 3 months, combined with 2 or more of the following: 1) relief of symptoms after defecation; 2) change in frequency of defecation during episodes; 3) change in stool characteristics (appearance) during episodes. The symptoms appeared at least 6 months before the diagnosis, and the above criteria were satisfied in the last 3 months. 2.After 12 weeks of conventional treatment (pivotal ammonium bromide or gastrointestinal motility drugs + diet adjustment + lifestyle adjustment, as well as antispasmodic, regulation of intestinal flora, etc.), the treatment is still ineffective or has little effect. (Please combine the specific medication with the clinical situation and be guided by the doctor’s interview.) Must exclude: 1. those with organic or infectious diseases of the digestive system or history of gastrointestinal surgery; 2. those with heart disease, diabetes mellitus, thyroid disease, central nervous system pathology, liver and kidney function impairment and gynecological organic diseases.