There are many kinds of vitamin B, collectively known as vitamin B, which can be easily absorbed by the body, promote the body’s metabolism, can improve the body’s immune function, help patients to enhance appetite, promote growth and development, etc. Vitamin B is generally not affected by time constraints, if lacking in any time to supplement can be taken at night, will not affect the effect of the drug, but is not recommended to take before bedtime. Patients are not advised to take it before bedtime because there are large individual differences and some patients have more sensitive bodies, such as taking vitamin B before bedtime may lead to symptoms of insomnia, etc. Some patients, such as those who are pregnant or breastfeeding, have stomach ulcers, diabetes, or are taking other drugs or allergies, should also be used with caution under the guidance of a doctor. When patients take B vitamins in their daily life, they should choose the time when they are taken with good effect. For example, vitamin B2 and vitamin B1 are mainly absorbed through the small intestine after oral intake, so they should be taken after meals to achieve a better effect. When patients choose to take vitamin B, they should pay attention to the amount of medication under the guidance of a doctor according to their personal situation. Long-term use or overuse of vitamin B may lead to the body’s dependence on vitamin B, and even symptoms such as irritability and loss of appetite.