Creatinine 190μmol/L is considered to be elevated, mostly due to physiologic and pathologic factors. Physiological factors are usually not serious, while pathological factors such as acute renal failure and chronic renal failure are relatively serious as they may lead to uremia in some patients if not treated actively. 1. Physiological factors are mostly seen after strenuous exercise or consuming a large amount of meat food, which will enhance muscle metabolism, creatinine production will increase, and the blood creatinine may be 190 μmol/L. However, the blood creatinine will return to the normal level after resting or vegetarian diet, which is usually not serious. 2. Acute renal failure: acute renal failure is caused by pre-renal factors such as nausea, vomiting, diarrhea caused by blood volume insufficiency; renal factors such as glomerular disease, tubular disease, etc.; post-renal such as urinary stones and other obstruction; most of the patients with acute renal failure will be restored to a healthy level after treatment under the guidance of the doctor and is not particularly serious. 3. Chronic renal failure: chronic renal failure can be caused by glomerular diseases such as chronic glomerulonephritis, and other secondary diseases such as hypertensive nephropathy, diabetic nephropathy, systemic lupus erythematosus, etc. Chronic renal failure is irreversible, and need to be treated with medication under the guidance of a doctor to slow down the progression of the disease, which is more serious. When creatinine 190μmol / L, the patient needs to go to the regular hospital in a timely manner, follow the doctor’s instructions to carry out the appropriate examination, to clarify the cause of the disease and then carry out symptomatic treatment, so as not to delay the condition.