1.Can gallstones be prevented by drugs? It is clear that, strictly speaking, gallbladder stones cannot be prevented by drugs. Gallstones are mainly divided into cholesterol stones and bilirubin stones, the former are related to high fat, high cholesterol, high sugar diet structure and lack of energy-consuming exercise after meals, long-term unreasonable diet leads to increased burden of liver decomposition, imbalance of bile acid and cholesterol ratio in bile, cholesterol crystals precipitated as gallstones, so these stones are mostly found in people with good economic conditions and specific occupations. There are no specific drugs that can regulate the ratio of bile acids to cholesterol in a high energy diet, so it is impossible to prevent cholesterol stones with drugs. Simple bilirubin stones are rarely found in the gallbladder, but most bile duct stones are found in the intra- and extra-hepatic ducts in combination with infections. Most of these stones are found in rural areas and in areas with poor sanitation. Again, there are no specific medications to prevent the development of gallstones. In general, the prevention of gallstones should be based on a healthy diet, drinking plenty of water, aerobic exercise and good hygiene practices. There is no statute that explicitly prevents the formation of stones, so once gallbladder stones occur, the focus is on treatment rather than on preventing further stone growth. 2. Can gallstones be removed by lithotripsy? The physiological anatomy of the human liver and biliary system determines that its ducts do not go straight like the kidneys and ureters, the latter may be discharged by urine after lithotripsy, while gallstones may be discharged by fluke as choledocholithiasis, which may lead to cholangitis, obstructive jaundice and shock in severe cases. Traditional anti-inflammatory and cholestatic drugs can help to relieve the symptoms of cholecystitis and regulate the contraction of the gallbladder and bile duct outlet sphincter. Therefore, lithotripsy is not suitable for gallbladder stones, and laparoscopic cholecystectomy is the most effective treatment for gallstones in the world. In the long run, there is a possibility of stone recurrence and recurrent inflammation after cholecystectomy, and this procedure is controversial. 3. Will gallbladder removal seriously affect the digestive function? This is a question raised by almost every patient, who treats the gallbladder as the only digestive organ in the body, and there seems to be a consensus that “how to digest without the gallbladder”. In fact, the gallbladder is only a small organ attached to the liver, the largest digestive organ in the body, and has the functions of temporarily storing and concentrating bile, secreting mucus, and emptying bile for intestinal digestion, but these functions overlap with those of the liver. However, when the gallbladder is abnormal due to gallbladder disease, it can seriously affect the digestive function, so it is important to weigh whether to remove or keep the gallbladder. For this reason, a normal diet is possible after a short adaptation period after gallbladder removal, and no special dietary restrictions are necessary.