Depending on the severity of atherosclerosis of the left lower extremity, functional exercises, oral medications, and interventions are available. Atherosclerosis of the left lower limb will cause pale skin, progressive pain and numbness of the distal limb. In the early stage, it is necessary to limit the physical activities, and the limbs are in a state of prolapse when lying in bed, so it is possible to promote collateral circulation and relieve limb ischemia through active muscle contraction, walking slowly on the ground and other exercises. Oral vasodilating as well as antiplatelet agglutinating drugs, such as hexacosanol, aspirin and cilostazol, can be taken to dilate blood vessels and improve blood supply. If atherosclerosis causes severe narrowing of the diameter, interventional therapy, such as percutaneous endovascular rotary cutting or rotary milling, can also be chosen. If atherosclerosis results in complete occlusion of the left lower extremity artery, surgical treatment, such as bypass grafting using the autologous saphenous vein, may also be an option. If the symptoms of atherosclerosis of the left lower limb appear, it is recommended that the patient go to the hospital to improve the examination and receive regular treatment.