Dry and peeling skin on the hands need to choose different medications according to different diseases, common causes include ringworm, hand eczema, exfoliative keratolysis and so on. 1. Ringworm: ringworm is a skin disease caused by dermatophyte infection, manifesting itself as peeling, blistering, drying and other symptoms on the skin surface, which may be accompanied by itching. Local topical miconazole nitrate ointment, bifonazole cream, etc., if necessary, oral medication can be used, such as itraconazole capsules, terbinafine hydrochloride tablets. 2. Hand eczema: chronic hand manifestation of the affected skin infiltration of dark red spots with papules, scratches and scales, local skin hypertrophy, surface roughness, self-consciousness, but also obvious itching, can be used externally with glucocorticosteroids, such as mometasone furoate cream and so on. 3. Exfoliative keratolysis: occurs in the palms or soles of the feet, mainly manifested as peeling, peeling serious local dry discomfort, often accompanied by sweating performance. Urea ointment, vitamin E ointment, petroleum jelly can be used topically. All of the above drugs should be used under the guidance of a professional doctor, avoid self-medication. Dry and peeling hands may also have other causes, it is recommended to go to the hospital in a timely manner, improve the examination, clear cause, give targeted treatment.