Hepatitis B DNA test results from negative to positive generally indicates that there is hepatitis B virus replication in the body, indicating that a healthy person is infected by the hepatitis B virus, or the DNA replication of chronic hepatitis B patients is more active than before. Hepatitis B virus DNA test is mainly used to determine whether there is hepatitis B virus replication in the body, when the result is negative, it means that there is no virus in the body, or the virus replication is inactive and the copy number is low, when the result changes from negative to positive, it means that the human body is infected with hepatitis B virus, or the virus replication of patients with chronic hepatitis B is more active, and the strength of the contagiousness needs to be determined based on the results of hepatitis B virus DNA quantification. The strength of infectiousness needs to be determined according to the results of hepatitis B virus DNA quantification. If the hepatitis B virus DNA quantitatively higher, also need to screen hepatitis B five, liver function, abdominal ultrasound and other tests, if necessary, under the guidance of the doctor to protect the liver, antiviral and other symptomatic treatment, follow the doctor’s instructions for regular review, avoid smoking and alcohol during the treatment period, avoid staying up all night, and dietary avoidance of spicy and stimulating food.