Gallstone disease is predominant in middle-aged and elderly people, and twice as common in women as in men. The middle-aged and elderly people generally exercise less and their basal metabolism decreases at an average rate of 0.5% per year. The nerve function that controls the bile discharge from the biliary system is also declining, and the contraction of the gallbladder and bile ducts is weakened, making it easy for bile to stagnate and lead to the formation of stones due to the accumulation of cholesterol or bile pigments. Secondly, middle-aged and elderly people are fat and have disorders of body fat metabolism, resulting in an increase of substances (mainly cholesterol and bile pigments) that contribute to stone formation in bile, especially in women, so middle-aged women are a high-risk group for gallstone disease. In addition, bile duct infections, bile duct roundworms and other diseases suffered during youth, bacteria, roundworm infections, eggs, dead worm residues, etc., can be used as the core to form stones when they are delayed until middle age. People who often do not eat breakfast Because of the long fasting time, bile is stored in the gallbladder for a long time to form stagnation, water reabsorption increases, excessive concentration, resulting in the deposition of cholesterol in the bile in the gallbladder, gradually forming stones. Prevention of gallstones should pay attention to: a. Diet should be regular, not overeating or starving a full meal. Regular eating (three meals a day) is the best way to prevent stones, because the gallbladder is full of bile when fasting, and the gallbladder mucosa absorbs water to thicken the bile, when cholesterol/lecithin bubbles are easily formed, and the viscosity of bile increases, finally forming bile sludge. If you eat, when food enters the duodenum, the gallbladder contraction hormone is secreted in response, causing the gallbladder to contract, and then a large amount of bile containing bile sludge is discharged into the intestine. Therefore, stone formation can be prevented. Food should be light, and less greasy, fried and baked food should be eaten. Do not eat too much high-fat food to prevent obesity. Drink a glass of milk every night or eat a fried egg for breakfast to make the gallbladder contract and empty regularly, so as to reduce the residence time of bile in the gallbladder. Choose a reasonable diet structure and avoid a high protein, high fat, high calorie diet. Appropriate consumption of fiber-rich foods to improve cholesterol excretion and prevent the formation of stones. Third, pay attention to dietary hygiene. Biliary tract ascariasis is one of the causes of gallstone disease. Fourth, maintain the contractile function of the gallbladder to prevent long-term bile depression. For patients who use intravenous nutrition for long-term fasting, gallbladder contraction drugs, such as cholecystokinin, should be used regularly. Actively treat some primary diseases that can cause gallbladder stones. Such as hemolytic anemia and hepatic sclerosis, as these diseases tend to induce gallbladder cholecystolithiasis. In people with hypothyroidism, poor thyroid function leads to a decrease in the body’s basal metabolic rate and a corresponding decrease in digestive function, gallbladder and bile duct contraction, causing bile outflow to become slower, stagnant and concentrated and precipitated, thus causing stones. Hepatitis can cause hepatocyte degeneration and thus cannot produce healthy bile, which can also cause stones. Fifth, avoid dietary hobbies, sweet tooth, excess sugar will stimulate insulin secretion, so that the synthesis of glycogen and fat increased, while cholesterol synthesis and accumulation also increased, resulting in increased cholesterol in the bile, easy to lead to gallstones. Excessive consumption of fatty foods increases the bile pigment and cholesterol content in the bile and causes precipitation, which gradually forms stones. In long-term vegetarians, the formation of stones is certainly related to excessive fat and high cholesterol, but it depends more on the solubility of cholesterol. In normal people, cholesterol is mixed with bile salts and lecithin in a certain ratio in the form of microcolloid particles suspended in the bile, and when this ratio is disrupted, gallstones are formed. Some vegetarians do not consume enough lecithin, and the excess fiber in the vegetarian diet prevents the reabsorption of bile acids, causing the concentration of bile salts in the bile to decrease. Insufficient lecithin and bile salts lead to an imbalance in the ratio, resulting in stone formation. Prevention should also be noted, to change the sedentary lifestyle, more walking, more exercise. It is also necessary to nourish the sex, people who are not in a good mood can trigger or aggravate this disease, to be broad-minded and in a good mood.