As a malignant tumor with high morbidity and mortality, the prognosis of gastric cancer is related to many factors such as gender, age, Borrmann’s staging, differentiation degree of tumor cells, and lymph node metastasis. Aggressive and effective comprehensive treatment can bring better prognosis. Many studies in recent years have gradually shown that aggressive postoperative chemotherapy did not bring significant survival benefit to patients with progressive gastric cancer, and only in patients who obtained effective resection could postoperative chemotherapy play some role. Radical resection is undoubtedly the most critical factor affecting the prognosis of patients with gastric cancer. We selected all radical surgery cases to analyze the factors affecting the prognosis of gastric cancer on the basis of a larger sample. It was found that gender had no significant effect on postoperative survival rate, which was consistent with the literature. The effect of age on the prognosis of gastric cancer varies among reports; Koea et al. reported that the poorer prognosis of gastric cancer in young people under 40 years of age was mainly related to the poorer histological type, later clinical stage and lower surgical resection rate of gastric cancer in young people; while relative to gastric cancer patients over 60 years of age, their prognosis was better due to their better histological type and slower progression. In our study, we found that the 5-year survival rate of gastric cancer in the young group was not significantly different from other age groups (p>0.05). Among the 31 gastric cancer patients in the ≤40-year-old group in our study, 9 cases of undifferentiated carcinoma, 11 cases of hypodifferentiated adenocarcinoma, 7 cases of indolent cell carcinoma and 4 cases of differentiated adenocarcinoma mainly belonged to the types with poor prognosis, but 12 cases of stage I gastric cancer, 8 cases of stage II patients, 5 cases of stage IIIa patients, 4 cases of stage IIIb patients and 2 cases of stage IV among these 31 patients, and the TNM stage of the tumor was more than half of the cases of stage I and II More than half of the cases were in the TNM stage of the tumor, which was significantly better than all other age groups. Further analysis revealed that young patients often came to the clinic soon after the onset of symptoms such as gastric discomfort or vague pain, and all of them were requested to undergo gastroscopy or GI examination to confirm the diagnosis. The average duration of preoperative disease was 4.5 weeks (2-14 weeks), which was significantly shorter than the average of 10 weeks (4-40 weeks) in other groups, and young gastric cancer patients had a shorter preoperative course and earlier tumor stage when they sought medical care. Therefore, we believe that among the factors influencing the prognosis of gastric cancer, the TNM stage of the tumor has a more pronounced effect on the prognosis than the histological type of the tumor. The location of the tumor is closely related to the prognosis of gastric cancer. After comparing the lymph node metastasis of tumors in different sites, we found that the average number of lymph node metastasis of extensive cancer with tumors occupying more than two subdivisions and gastric cancer located in the proximal part was significantly higher than that of other sites. The reasons for this are as follows: ① extensive cancer occupying more than two subdivisions has a wide range of lesions, late stage of disease, and higher lymph node metastasis, so the prognosis is worse. ②The cancer in the proximal part of the stomach has hidden clinical symptoms and is not easily detected at an early stage, and the high degree of lymph node metastasis is related to its late stage. Among 83 cases of early gastric cancer in our study, two cases had lymph node metastasis although the lesions were confined to the mucosa, and died of recurrent metastasis 18 and 37 months after surgery, respectively, which further proved the importance of lymph node metastasis to the prognosis. The prognosis of patients with Borrmann type I and II gastric cancer was significantly better than that of patients with type III and IV, with type IV being the worst. 45 patients in this group had the longest survival of 36 months and the shortest of 4 months, with a median survival of 9 months and a 5-year survival rate of 0. Of the 45 patients with Borrmann type IV gastric cancer, 38 patients had lymph node metastasis and died at 18 and 37 months postoperatively, respectively. Among the 45 patients with Borrmann type IV gastric cancer, 38 cases were extensive cancers with tumors occupying more than two divisions of the stomach, accounting for 84.4%. Among the 45 patients with Borrmann type IV gastric cancer, 38 had extensive cancer with tumors occupying more than two subdivisions of the stomach, accounting for 84.4% of the cases, while in the other Borrmann type I, II and III groups, the percentages were 13.9%, 14.3% and 24.9%, respectively. Meanwhile, lymphatic metastases occurred in all Borrmann type IV, and the mean number of lymph node metastases was also higher than that in all other groups. The depth of tumor infiltration reached or exceeded the plasma membrane layer, and the TNM stage of the tumor was late, which was the main reason for its poorer prognosis. In this study, the failure of the gross staging of gastric cancer into the model did not mean that the gross staging of gastric cancer was an irrelevant factor in the prognosis of gastric cancer, but probably the depth of infiltration and the degree of lymph node metastasis in the model took its place. The depth of tumor infiltration and the degree of lymph node metastasis were closely related to the prognosis of the tumor. The 5-year survival rate of gastric cancer patients gradually decreased from 97.6% in the T1 group to 10.2% in the T4 group as the depth of tumor infiltration gradually deepened; the more lymph node metastasis, the 5-year survival rate of patients gradually decreased from 85.5% in the N0 group to 0 in the N3 group. The TNM stage of tumor included the depth of tumor infiltration and lymph node metastasis, and the later the TNM stage, the worse the prognosis of patients. There was a significant difference in 5-year survival rate between the groups.