Hard lumps under the skin that hurt when pressed may be due to sebaceous cysts, gout stones, lipomas and other factors, you need to clarify the disease and then treat the symptoms, common treatments include surgery, medication, life adjustments and so on. 1. Sebaceous cyst: It is formed when the sebaceous gland ducts are blocked and the contents of the glands accumulate, manifesting as a round swelling on the skin with a smooth surface, which can be painful when secondary infection occurs. Treatment is based on surgical incision and removal of the swelling, and antibiotics are required for treatment of infections. 2. Gout stone: It is a crystal formed by glutamate gathering under the skin, commonly found in the auricle, manifested as yellowish-white nodules protruding from the skin surface, accompanied by pressure pain, joint swelling, joint dysfunction and other symptoms. The treatment mainly focuses on reducing the uric acid content in the body, such as lifestyle change, drug treatment (febuxostat, ligustroxime), alkalinization of urine, surgical treatment and so on. 3. Lipoma: it is a common benign tumor of soft tissue, which occurs in the limbs and trunk, and is usually a small painless lump, a few lipomas can cause local pain due to compression of nerves, and multiple lipomas can be accompanied by pain. Lipomas usually do not require treatment, but surgery is needed when uncomfortable symptoms occur. Hard lumps under the skin can be painful when pressed, which may also be caused by other factors. It is recommended that the patients should seek medical treatment in time, actively cooperate with the relevant examinations, clarify the causes of the disease, and follow the doctor’s instructions to standardize the treatment, avoiding the use of private medication, so as to avoid delaying the condition.